Newsletter registration

By using our website, you are agreeing to cookies being stored and Google Analytics being used on your device in order to offer the best possible service. You can find more information on thishere.
Austria.
Where Your Profits Grow Sky High.

Bacteria compensate for fitness loss through antimicrobial resistance

Photo: APA (Fohringer) © Photo: APA (Fohringer)

The antibiotic Rifampicin inhibits an enzyme in bacteria cells with which read the genetic material in order to build a model for proteins (RNA polymerase). If this enzyme is changed, it cannot be attacked by antibiotics, but does not function as efficiently any more, and the microbes’ “fitness” deteriorates.

In the case of Pseudomonas-aeruginosa bacteria, the researchers discovered that these pathogens slowly but surely compensate for a fitness loss by means of a Rifampicin resistance. They can simply compensate for small handicaps by ensuring that other cellular functions become even more effective. The overall fitness level once again resembles the fitness of the non-resistant bacteria.

However, if the fitness loss is considerable as a consequence of the resistance to the antibiotics, they process no longer works. In this case the bacteria have to completely restore the function of the enzymes by detours. The scientists reported that this is up to 10,000 times more difficult (less probable). The study is designed to contribute to an understanding of the dynamic processes involved in a spreading of antimicrobial resistance, especially in a clinical environment. 

Share on Facebook Share on Facebook Share on Twitter Share on Twitter Share on Linkedin Share on Linkedin

Testimonials

Events

Meet us at events, seminars and trade shows - worldwide.

Austria Map

Find the perfect location for your company

Austria offers the comfort and infrastracture of a western industrial nation. The high quality of life is an advantage when it comes to attracting top executives from around the world to our headquarters here.

Coca-Cola Austria

Logo
More testimonials

news from the business location Austria

Medical University of Vienna: New therapy option doubles the life span of B-cell lymphoma patients

The so-called CAR-T cell therapy is a promising option for treating around one fifth of patients with diffuse large B-cell lymphoma.

Ski Tourism as an Attractive Business Driver in Austria

Famous for its culture and unspoiled natural environment, Austria attracts vacationers and tourism companies from all over the world. One major advantage is the central location in the heart of Europe and the related good accessibility.

More news All blog posts