Newsletter registration

By using our website, you are agreeing to cookies being stored and Google Analytics being used on your device in order to offer the best possible service. You can find more information on thishere.
Austria.
Where Great Emphasis is Put on Research.

Targeted inhibitors help against cancer – removal is harmful

"There are an increasing number of outbreaks of cancer, especially blood cancer, in which the hyperactivity of Tyk2 is the cause“, explained Mathias Müller of the Institute of Animal Breeding and Genetics at the University of Veterinary Medicine in Vienna. The signal conveyors can also trigger excessive immune reactions.

For this reason, substances are being developed which inhibit the previously known function of Tyk2 (or "kinase"). Signals are transmitted by attaching a “flag” (phosphate residue) to other proteins. Such medicines would be helpful in the fight against cancer and inflammation-related illnesses, the researchers say.

However, complications could arise in light of the fact that Tyk2 makes a considerable contribution to the maturing and activation of “natural killer cells”.  

In fact, mice in which completely lacked Tyk2 had killer cells which were baldy prepared, and could no longer control cancer growth. However, in animals in which Tyk2 was present but its kinase activity was inactivated, cancer growth was strongly suppressed and the natural killer cells retained their ability to effectively kill the cancer cells.

"Medicines aiming to inhibit kinase activity do not damage the work of the immune system“, explained Birgit Strobl of the Department for Molecular Genetics at the University of Veterinary Medicine in Vienna. Instead, they are more promising for cancer therapy than was originally thought. 

Share on Facebook Share on Facebook Share on Twitter Share on Twitter Share on Linkedin Share on Linkedin

Testimonials

Events

Meet us at events, seminars and trade shows - worldwide.

  • 4. Mittelstandsforum Nordrhein-Westfalen

    18.06.2019, Dusseldorf, Germany

  • Expand to Austria

    26.06.2019, Brescia, Italy

Austria Map

Find the perfect location for your company

A country like Austria considered to be an especially good terrain for upscale industrial segments, and with a particular emphasis on research and environmental friendliness, represents a major opportunity for SIAD. Our corporate goal is namely to assist the customer and provide support in improving the productivity and the environmental compatibility of its work processes.

SIAD

SIAD
More testimonials

news from the business location Austria

A.T. Kearney: Austria improves in the investment ranking

The inflows related to foreign direct investments in Europe in 2018 fell by 73 percent to USD 100 billion from the prior-year level of USD 372 billion.

Innovations from Austria for the Logistics Sector

At the present time there are many influencing factors which pose challenges to the supply chain and logistics management. Solutions in this area are frequently developed by startups, also from Austria. Several of them will present their innovations at the Austrian Logistics Day and Logistics Future Lab.

More news All blog posts