Newsletter registration

By using our website, you are agreeing to cookies being stored and Google Analytics being used on your device in order to offer the best possible service. You can find more information on thishere.
Austria.
Where Your Profits Grow Sky High.

Antibodies neutralize LDL cholesterol

Photo: Markus Steiner © Photo: Markus Steiner

The study published in "Cell Reports" originated with scientists led by Christoph Binder, Group Leader at the CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences and atherosclerosis researchers at the Medical University of Vienna.  

In occurrences of vascular calcification, “bad” LDL cholesterol is stored in vascular walls. Harmful oxygen radicals arise on the basis of oxidation, which in turn cause the inflammation. Macrophages (scavenger cells) move to the walls of the arteries and bind the oxidized LDL blood fat, convert them into foam cells and further strengthen the inflammation through immune system messengers.  

A certain group of white blood cells – B-1 cells – work against the life-threatening damage to vessels that can lead to heart attack and stroke. These cells produce naturally occurring antibodies that bind oxidized LDL and neutralize it, disrupting the inflammation. The immune cells also carry a molecular regulator that reduces their activity, said Sabrina Gruber, the first author of the study and PhD student at CeMM.

 “We were able to show that the deactivation of this regulator, the so-called 'Siglec-G' protein, caused an increased propagation of B1-cells and antibodies, which protect vessels and the liver from inflammation”, the scientist added. 

Share on Facebook Share on Facebook Share on Twitter Share on Twitter Share on Linkedin Share on Linkedin

Testimonials

Events

Meet us at events, seminars and trade shows - worldwide.

Austria Map

Find the perfect location for your company

Vienna is the driving force for innovations in our company,
and one of the growth drivers.

Ottobock Austria

Logo
More testimonials

news from the business location Austria

Medical University of Vienna: New therapy option doubles the life span of B-cell lymphoma patients

The so-called CAR-T cell therapy is a promising option for treating around one fifth of patients with diffuse large B-cell lymphoma.

Ski Tourism as an Attractive Business Driver in Austria

Famous for its culture and unspoiled natural environment, Austria attracts vacationers and tourism companies from all over the world. One major advantage is the central location in the heart of Europe and the related good accessibility.

More news All blog posts