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Cancer research: Viennese startup breaks new ground in drug research

Stefan Ameres and Johannes Zuber © IMBA

The new start-up QUANTRO Therapeutics at the Vienna BioCenter uses innovative transcriptome profiling technologies in a novel drug discovery pipeline to identify and develop effective anti-tumour therapeutics. The company is a spin-off resulting from the long-standing research cooperation between the institutes IMP and IMBA as well as the pharmaceutical company Boehringer Ingelheim and the Austrian Academy of Sciences. QUANTRO received a seed investment from the Boehringer Ingelheim Venture Fund and Evotec.

Cancer is a leading cause of death and one of the most complex challenges to modern medicine. The new startup QUANTRO Therapeutics employs cutting-edge technologies that precisely measure the effects of candidate targets and drugs on the fundamental cell process of transcription as a means of developing new drugs. By carrying out comparative analyses of such "transcription fingerprints", a completely new type of highly precise process for cell-based screens for new active ingredients. In the initial applications, QUANTRO is focusing on the discovery and development of chemical substances which interfere with cancer-associated transcription factors. This represents a class of particularly promising targets that have so far remained largely inaccessible for drug therapy.

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