By using our website, you are agreeing to cookies being stored and Google Analytics being used on your device in order to offer the best possible service. You can find more information on thishere.
Where Your Profits Grow Sky High.

Progress in personalised cancer medicines

illustration: monkey and electric sparks ©

Basic researchers led by Eduard Stefan have further developed this technology in order to be able to predict whether drugs can inhibit certain kinases, whose mutations can trigger cancer. Signalling pathways in human cells can be damaged by mutations in kinases, which act as molecular switches. Frequently the consequences are serious diseases such as cancer. For several years now modern-day medicine has had the means to take targeted action against mutated kinases. In the meantime, more than 60 kinase inhibitors have been approved for clinical applications.

The scientists led by Eduard Stefan of the Department of Biochemistry and the Centre for Molecular Biosciences at the University of Innsbruck have now investigated whether BRAF inhibitors can also have an effect on other tumorous diseases. For this purpose, they used a biosensor technology developed at the University of Innsbruck for which a patent application has been submitted. In this process, the two ends of the kinase protein are fused with two reporter protein fragments and expressed in cells. "If the mutated kinases in the cells are deactivated by the inhibitor, the structure of the kinase changes. In the case of the kinase BRAF, the two ends of the enzyme move closer together, as do the two reporter protein fragments. They interact and increasingly begin to glow in the cell", says Eduard Stefan, talking about the effects of the KinCon biosensor. In this way, the researchers can directly keep track of the pathological function of various ONCO kinases in intact cell populations.

"Such biotechnological approaches pave the way for new concepts in personalised medicine, with which one can hope to find the appropriate medicine for patients", says Eduard Stefan. The biochemist Eduard Stefan now wants to expand the biosensor platform KinCon to other classes of kinases, and thus make a decisive contribution on the search for personalised drugs.

Continue reading and find out more about the life sciences sector in Austria.

Share on Facebook Share on Facebook Share on Twitter Share on Twitter Share on Linkedin Share on Linkedin



Meet us at events, seminars and trade shows - worldwide.

  • Life Sciences Wien - Ein Markt mit vielen Chancen

    28.01.2021, 10:00 - 11:30 (CET), Online Conference

  • Meet us @ HTH Styria!

    28.1.2021, 10:00 - 16:15 (CET) , Online Conference

Austria Map

Find the perfect location for your company

Austria is well known for its social stability and excellent labor relations where strikes are measured only in seconds. As a global player, reliable deliveries are a top priority for us.

Opel Austria

More testimonials

news from the business location Austria

Austrian government creates investment premium for investors

The economic and financial consequences of the COVID-19 crisis pose major challenges to companies. In order to strengthen the Austrian business location, the Austrian Federal Government has resolved upon a new investment promotion program for companies with a total volume of EUR 3 billion, which will be further increased, if necessary.

Support measures for companies affected by COVID-19

To stimulate the economy, either new programs may be established as a result of the draft law or existing support programs (e.g. aws, ÖHT) will be expanded. All measures introduced are intended to be applicable immediately and will be in force until the end of 2020. The measures currently introduced include the following areas:

More news All blog posts