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SARS-CoV2 vaccination: Thrombosis can be prevented by prompt treatment

researcher in protection suit, microscope © Medical University of Vienna

This involves thrombosis at unusual places in the body, associated with a low thrombocyte (blood platelet) count and a clotting disorder. In medical jargon, this syndrome is referred to as VITT (vaccine-induced thrombotic thrombocytopenia) or a vaccine-caused shortage of blood platelets. The VITT syndrome is most probably caused by a defective immune response, whereby thrombocyte-activating antibodies are produced resulting in thrombocytopenia (low platelet count) and thrombosis. The mortality rate in VITT is high (40-50 percent) and the syndrome requires immediate and appropriate treatment.

A team of doctors at the Department of Internal Medicine of the Medical University of Vienna (MedUni Vienna) and Vienna General Hospital successfully treated a patient suffering from vaccine-induced prothrombotic immune thrombocytopenia (VIPIT). The female patient was admitted to the department with a low platelet count and low fibrinogen levels, but still without a thrombosis. Fibrinogen is a protein that plays a major role in blood clotting. Indications of an impending thrombosis were extremely high, and doctors immediately began treatment with a high dose of intravenous immunoglobulin concentrates, cortisone and specific anticoagulants, so that thrombosis was prevented. These new findings were published in the Journal of Thrombosis and Haemostasis.

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